5 Natural PDE5 Inhibitors: Powerful Natural Supplements

OTC Supplements

This article is going show you 5 Natural PDE5 Inhibitors Supplements and explain how they can increase erection strength in men.

PDE5 inhibitors prevent the breakdown of cGMP in the blood vessels that supply the penis which is exactly what Viagra does.

5 Potent Natural PDE5 Inhibitors

And if you want strong erections, you need to know that the substance guanosine monophosphate (cGMP) is very important. 

The reason it's so important is because it's this substance that helps red blood cells give up nitric oxide which in turn helps improve blood flow to the penis.


But when PDE5 is too high in the body, it will go about reducing cGMP which in turn will lower our chances of having strong erections.

This is why these 5 inhibitors mentioned below can help men with erectile dysfunction by increasing blood flow to the penis.

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Icariin Extract

The first natural inhibitor on the list is Icariin extract which is the main ingredient in horny goat weed.

Icariin has been used for thousands of years in Chinese culture as a natural ed cure and now research is shedding light on why.

This extract has been shown to have testosterone-like effects on the body such as nerve stimulation and increased sexual effects.

Studies have also shown Icariin to be a supplement that can also increase testosterone levels because of increased activity in cholinergic neurotransmitters which are linked to sexual arousal.

Another factor is that Icariin works on regulating the production of cortisol in the body, something that can depress testosterone levels if it becomes very high. The recommended dosage for Icariin is 250-1000mg per day.

A tincture is a good way to get icariin straight into the blood. To find a tincture click here.

To get horny goat weed in an extract that contains 20% icariins and water extracted click here


Pycnogenol is a plant extract that comes from the bark of a french maritime pine which grows in southwest France.

The reason that Pycnogenol is one of the best supplements to increase erection strength is because of its amazing ability to improve nitric oxide production.

It does this by helping to increase the enzyme nitric oxide synthase (NOS) which is an enzyme that supports nitric oxide production in the body.

Other studies have shown how Pycnogenol is a useful natural PDE5 inhibitor. For instance, one study showed that Pycnogenol had better results than typical medication for men suffering with leaky vein syndrome (another cause of erection problems).

Here are some of the benefits of Pycnogenol for men

  • Acts as a powerful antioxidant
  • Reduces blood pressure
  • Lowers blood sugar
  • Help improve leaky vein syndrome
  • A Proven Natural Inhibitor

When it comes to the best dosage for Pycnogenol you want to take a dose of around 50mg 1-3 times per day.

The only difficulty you will encounter is where you can buy Pycnogenol from that is not too expensive.

Because Pycnogenol is patented the price is usually a lot higher than most supplements. The only way around this is to buy from a reputable online website Twinlabs Pycnogenol 50mg, 60 Capsules


Forskolin is mainly known for its ability to affect glaucoma and also as a fat burner. But what nobody seems to know, is that it can increase testosterone and it's a natural PDE5 inhibitor.

Studies have shown that taking forskolin can see increases as high as 34% in bioavailable testosterone when taking as little as 50mg a day.

The ability of Forskolin to burn fat also supports the lowering of aromatase in the body, which in turn helps increase testosterone and libido.

Forskolin is a cAMP activator which means that it acts as a messenger that activates certain proteins to bind with DNA sites, in this case within the muscles.

Forskolin is so effective because it stimulates all forms of the adenylyl cyclase enzyme but doesn't activate any other receptors, unlike ephedrine. It is found in most subtropical regions and has a history of use in Ayurvedic medicine.

The increase in cAMP activity also means that you can expect better performance due to more muscle contractions. Many celebrities use forskolin to get ripped and many celebrity trainers endorse it.

The optimum dosage amount is 500mg a day with a minimum of 10% forskolin in the supplement.

The best quality Forskolin can be found from a company that has the correct potency of 20% and is manufactured in an FDA Approved and GMP Certified Facility.

To find out more about this company click here.


Arginine is another great PDE5 inhibitor and joins our list of supplements that increase erection strength for good reasons.

The reason that Arginine can help to improve erections is because one of the key functions of Arginine is to convert into nitric oxide.

Nitric oxide will improve blood flow and circulation in the body that will contribute to every area of health including heart health, brain health, and sexual health.

It is interesting to note that one of the ways that Viagra works is by slowing the breakdown of Nitric Oxide which then allows levels to increase in the body.

In a nutshell, Arginine will help to increase blood flow and improve erection strength.

Here is a short video showing how important circulation is.

Studies also show that when Arginine is taken along with Pycnogenol the nitric oxide boost is significantly increased. To see this study click here

So try this natural PDE5 inhibitor protocol which includes both arginine and pycnogenol.

Take 50-150mg of Pycnogenol with 1.5 grams daily of L- Arginine.

Tongkat Ali

Euryycoma Longifolia has been used in Chinese medicine for thousands of years as a strong and powerful aphrodisiac.

It is found all over southeast Asia, though the name Tongkat Ali comes from the Malay term for the plant and refers to a “superior walking stick” (virility)

Studies show that the levels of eurypeptides found in the plant help to improve energy.

It is these eurypeptides that are responsible for affecting testosterone levels by releasing them from their bond with the SHBG (sex hormone binding globulin).

As well as stimulating the production of Luteinizing Hormones which stimulates the production of testosterone it also reduces aromatization where excess testosterone is converted to estrogen.

High levels of estrogen can trick the brain into thinking that there is an excess of testosterone and thereby slow or stop the body's own production. Tongkat Ali helps prevent this by stopping the conversion of excess free testosterone.

This decrease in estrogen conversion is responsible for many of the athletic improvements that studies have noted.

When adult men added Tongkat Ali supplementation to their daily weight training regimen participants showed an improvement in lean body mass with greater arm circumference measurements than those taking a placebo version.

Abdominal fat mass was also seen to be reduced in the subjects. A study of adult men with lower than normal testosterone levels showed a massive 46% increase after only 12 weeks of supplementation.

Here are some studies that show the power of Tongkat Ali

1) In this study 32 men and 31 women were given a standardized extract of Tongkat and after just 4 weeks of taking the herb cortisol had been reduced by 16% and testosterone increased by 37%. This study shows how the reduction in stress this herb can offer will also benefit testosterone production, click here to see the study

2) In this study which involved 109 men and went on for 6+ months, half of the subjects were given 300 mg's of Tongkat and the other half were given a placebo. After just 12 weeks the results showed an increase in semen motility of 44% and volume increase of 18% only in the group taking Tongkat Ali, click here to see the study

3) This ergo-log study shows how Tongkat Ali increases testosterone in men who produce too little of the hormone, click here to see the study

Tongkat is one of the most powerful herbs for increasing testosterone and sexual vitality and when taken at the correct dosage and also cycled it will bring great benefits to anyone who uses it. To read a post about Tongkat Ali click here.

There are two companies that sell Tongkat Ali at the required strength to increase sexual vitality and they can be found here and here.


These 5 PDE5 inhibitors can be taken without the usual side effects that come from taking over the counter drugs like Viagra, Levitra and Cialis.

These herbs and supplements mentioned above also have other health benefits that can help men to live a healthy and energetic life.

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